Another great example of the Bioflux's ability to generate high quality data. This time in Nature: Scientific Reports, Nicolay et al., discuss how "Cellular stress induces erythrocyte assembly on intravascular von Willebrand factor strings and promotes microangiopathy"
High impact 2018 publications describe BioFlux platelet and immunology research Recent high impact research articles on platelet adhesion have demonstrated the utility of The BioFlux System. The Schneider group at University Medical Center Hamburg-Eppendorf in collaboration with University of Dortmund have described the interaction of von Willbrand Factor (vWF) fibers and erythrocytes. The work clarifies erythrocyte contributions to the pathology of vascular occlusion and was published in Nature: Scientific Reports. This study used BioFlux to study the adhesion of erythrocytes to vWF fibers under different shear forces.
Cellular stress induces erythrocyte assembly on intravascular von Willebrand factor strings and promotes microangiopathy, Nicolay et al., 2018
The University of Pennsylvania published an extensive study in Nature Communications characterizing a red blood cell (RBC) hitchhiking mechanism to carry nanoparticles to areas of the body. This mechanism avoids liver uptake by using RBCs to transfer nanoparticles to a targeted downstream organ. BioFlux was used for the ex-vivo portion of this study to examine leukocytes actively removing nanoparticles from RBCs under physiological perfusion.
Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude, Brenner et al., 2018