Avatar
Cell culture platform providing accurate environmental control and pressure to model tumour micro-environments
The xcellbio AVATAR™ System lets you fine-tune oxygen and pressure levels to cater culture conditions to your cell type of interest. Customising settings based on tumour type or native microenvironment allows cells to behave as they would in vivo
Introduction
The AVATAR™ Cell Control System lets you generate your cells of interest in the tumour microenvironment ((TME) to optimize growth rate, functional activity or phenotypic change of interest.
Using correct hypoxia conditions is now widely accepted among cell scientists (2019 Noble Prize for Medicine or Physiology, awarded to William Kaelin, Sir Peter Ratcliffe and Gregg Semenza). Today the next dimension is physiological pressure. The Avatar provides both controlled O2 and physiological pressures with absolute accuracy.
Key application areas for the AVATAR™ include:
Tumour Environment Modelling: Identify novel checkpoint inhibitors that work effectively under immunosuppressive tumour microenvironments
Stem Cell Differentiation: Enhance IPSC reprogramming and stem cell differentiation efficiency
Cell Therapy Optimisation: Enhance CAR-T potency, persistence and homing
Organoid Research: Generate organoids and spheroids that thrive under hypoxic culture condition
£0.00
- Specifications
- Features & Benefits
- Hypoxia and Pressure - Stem Cell Research
- Hypoxia
- Pressure
- Pressure - Gene Expression / Biomarkers
Temperature Range – 30 – 45 degrees C @ +/- 0.1% accuracy
Oxygen Range – 0.1 – 22% @ +/- 0.1% accuracy
Carbon Dioxide Range – 0 – 20% @ +/- 0.1% accuracy
Pressure Range – 0.1 – 5 psig @+/-2.5% accuracy
Chamber Capacity – 3.7 litres (224 cubic inches)
Dimensions (W × D × H) – 34.3 × 33.3 × 30.5 cm (13.5 × 13.1 × 12 in.)
Shipping Weight – 23 kg (51 lbs.)
Comprehensive Environmental Control
Carry out hypoxia and physiological pressure studies in the same system. Study how cells respond under physiological culture conditions
Target Your Chosen Cell Population
Tune your cell’s micro-environment to control differentiation or maintain the current state, both reliably and precisely. Model the tumour microenvironment
Cell Flexibility
Work with immune cells, stem cells, tumour cells, organoids and even rare, precious cells you’ve never been able to expand before
Expand Cells Easily
Expand challenging cell types easily and reproducibly for a broad range of primary cells, reducing reagent costs
Compact and Modular Design
~30 cm cube saving valuable benchspace. Modular design allows add-on units for parallel studies
ISSCR_June2017_Application of atmospheric pressure during culture promotes neural differentiation in iPSCs
Hypoxia – Cancer
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Hypoxia – Immunity
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Pressure – Cancer
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- Nathan, S. S., DiResta, G. R., Casas-Ganem, J. E., Hoang, B. H., Sowers, R., Yang, R., Huvos, A. G., Gorlick, R., & Healey, J. H. (2005). Elevated physiologic tumor pressure promotes proliferation and chemosensitivity in human osteosarcoma. Clinical Cancer Research, 11(6), 2389–2397. https://doi.org/10.1158/1078-0432.CCR-04-2048
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- Rofstad, E. K., Galappathi, K., & Mathiesen, B. S. (2014). Tumor Interstitial Fluid Pressure-A Link between Tumor Hypoxia, Microvascular Density, and Lymph Node Metastasis. Neoplasia, 16(7), 586–594. https://doi.org/10.1016/j.neo.2014.07.003
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- Wu, M., Frieboes, H. B., McDougall, S. R., Chaplain, M. A. J., Cristini, V., & Lowengrub, J. (2013). The effect of interstitial pressure on tumor growth: Coupling with the blood and lymphatic vascular systems. Journal of Theoretical Biology, 320, 131–151. https://doi.org/10.1016/j.jtbi.2012.11.031
Pressure – Immunity
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- Swartz, M. A., & Lund, A. W. (2012). Lymphatic and interstitial flow in the tumour microenvironment: Linking mechanobiology with immunity. Nature Reviews Cancer, 12(3), 210–219. https://doi.org/10.1038/nrc3186
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- Walmsley, S. R. (2019). Pressure regulates immune-cell function. Nature, 573(7772), 41–42. https://doi.org/10.1038/d41586-019-02339-4
- Wu, M., Frieboes, H. B., McDougall, S. R., Chaplain, M. A. J., Cristini, V., & Lowengrub, J. (2013). The effect of interstitial pressure on tumor growth: Coupling with the blood and lymphatic vascular systems. Journal of Theoretical Biology, 320, 131–151. https://doi.org/10.1016/j.jtbi.2012.11.031
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