Pu·MA System 3D

Automated 3D Cell-Based Assay Technology

The Pu·MA System 3D, consisting of the Pu·MA System and 3D Flowchips, automates assays for 3D cell models such as organoids, tumoroids or spheroids. The system maintains the organoids in a unique sample chamber that allows easy media, metabolite or reagent exchanges for oncology, drug testing, labelling, toxicology, or metabolomics research. This open platform enables multiparametric data collection from single organoid samples.

  • Automated “hands-off” workflow for complex assay protocols
  • Protected sample chamber to prevent organoid damage
  • Perform in situ media exchanges, compound additions and supernatant sampling
  • Compatible with high content imaging and plate reader systems

Types of assay steps that can be performed:

  • Multiparameter spheroid based Oncology assay (including primary, iPSC and patient derived tumoroids)
  • Immunofluorescence staining of 3D structures of high content imaging
  • Metabolite analysis
  • Sequential Drug Addition and downstream Analysis

In situ sampling

  • Cell Viability Assays
  • Functional Assays
  • Analysis of Matrigel grown organoid assays
  • 2º toxicology screening and HIT profiling

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