Measuring oxygen consumption rate (OCR) in physiologically relevant conditions

Lucid Resipher 32 and Baker InvivO₂ 300

Baker workstations allow researchers to adapt the environment (O₂, CO₂, temperature, and humidity) to suit the cells under investigation enabling tasks to be carried out under physiologically relevant conditions. Whilst the Lucid Scientific Resipher System turns a 96-well plate into a precise real-time oxygen consumption reader\u2014continually streaming oxygen consumption rate (OCR) in cell cultures from within the hypoxia/physoxia workstation or incubator.

Why combine the two?

Laboratories combining the tightly controlled environment, provided by the InvivO₂ 300 anaerobic workstation, with the real-time monitoring of the Resipher system benefit from:

• In situ metabolic profiling without disturbing the culture environment.
• True physiological relevance for studies in cancer, immunology, and stem cell biology.
• Improved reproducibility by combining real-time measurement with tightly controlled conditions.
• Reduced cost compared to the alternative solutions, such as an XF metabolic analyser.

This combination empowers researchers to observe how cells adapt metabolically to their oxygen environment\u2014in real time, over the full course of an experiment.

Lucid Scientific Resipher System

The Resipher is a non-invasive platform that continuously measures oxygen consumption rate (OCR) live, in 2D and 3D cell cultures, providing real-time metabolic data over hours, days, or even weeks. Designed for use inside standard incubators or hypoxia/physoxia workstations, the Resipher lets researchers capture the full metabolic profile of cells under physiological conditions\u2014without interrupting their workflow.

Unlike traditional endpoint assays, the Resipher enables:

• Continuous, label-free metabolic monitoring.
• In situ data collection without removing cultures from controlled environments.
• Long-term profiling for drug response, differentiation, or gene modulation studies.

Baker Physoxia InvivO₂ 300 Workstations

Baker\u2019s InvivO₂ 300 compact physoxia workstation provides precise, stable control of oxygen, CO₂, temperature, and humidity\u2014giving researchers the ability to mimic physiological or pathological conditions in vitro. Unlike standard incubators, these workstations maintain tightly regulated environments down to <1% O₂, critical for studying cell behaviour under hypoxia or physoxia.

InvivO₂ 300 workstation enables:

• Consistent oxygen control for extended culture under hypoxic or tissue-physiological conditions.
• Seamless workflows with full access to your cultures without exposing them to ambient air.
• Reproducible results ideal for metabolism, stem cell biology, cancer, and immunology studies.

Applications for this package include:

• Cancer metabolism
• Neuroscience / stroke models
• Immunology and infection
• Stem cell biology and differentiation
• Drug discovery and screening
• Tissue engineering and organoids