NanoDrop One

Micro-Volume Spectrophotometer

The Thermo Scientific NanoDrop One is the latest generation standalone instrument providing a clearer picture of sample quality

Features & Benefits

  • Acclaro™ sample intelligence
  • Contaminant Detection
  • Bubble Detection
  • Improve Measurement Integrity
  • Auto blank– Auto measure
  • Improve your Workflow
  • Compact standalone design
  • Reduce Bench Space impact

Applications

  • Simple operation- Pipette, Measure, Clean (as with the ND1000)
  • No specialist consumables required
  • Wide dynamic range 2 – 27,500 ng/ml ds DNA means no requirement for dilutions. The maximum concentration is ~8 fold higher than on the ND1000
  • 5 Auto ranging pathlengths ensure accurate data across the whole concentration range with no prior knowledge of sample concentration required
  • Automatic calculation of sample concentration, A260/A280 and A260/A230 Purity ratios
  • Dedicated Oligo calculation software module
  • Microarray module for labelling efficiency determination
  • Acclaro Sample Intelligence Technology
    • Identification of key contaminants with corrected concentration
    • Information alerts for abnormal purity ratios and issues with the blank
    • Digital image processing alerts to bubbles and anomalies with the sample that can affect measurement integrity
    • On-board guided troubleshooting and learning
  • Simple operation-Pipette, Measure, Clean (as with the ND1000)
  • No specialist consumables required
  • Wide dynamic range 0.06- 820 mg/ml BSA means no requirement for dilutions. The maximum concentration is ~8 fold higher than on the ND1000
  • 5 Auto ranging pathlengths ensure accurate data across the whole concentration range no prior knowledge of sample concentration required
  • Automatic calculation of sample concentration, A260/A280 and Purity ratio
  • Protein Editor allows input/saving of user defined protein information
  • Dedicated A205 module for quantification of peptides and proteins lacking tryptophan or tyrosine residues
  • Spectrograph with native low stray light and deep UV detection
  • Proteins and Labels Module for labelling efficiency determination
  • Pre-configured modules for colorimetric protein assays including Bradford, BCA, Lowry and Pierce 660
  • Acclaro™ Sample Intelligence Technology
    • Identification of key contaminants with corrected concentration
    • Information alerts for abnormal purity ratios and issues with the blank
    • Digital image processing alerts to bubbles and anomalies with the sample that can affect measurement integrity
    • On-board guided troubleshooting and learning
  • Compact stand alone design (no external PC required)
  • Auto blank and auto measure features streamline your workflow
  • Large glove compatible touchscreen interface with tilt – slide capability to ensure ergonomic operation
  • 3 USB ports for connectivity to external input devices (keyboard, mouse, barcode reader), USB flash drives or printer
  • Bluetooth connectivity for external keyboard
  • Wifi and Ethernet connectivity
  • Multi-language support
  • The NanoDrop™ One C model also includes an integrated cuvette reader with:
    • Heater and magnetic stirrer
    • The ability to use with arm up or down
    • Extended sensitivity (down to 0.2 ng/µl ds DNA and 0.006 mg/ml BSA)
    • Increased assay flexibility for OD measurements, protein assays, kinetics or sample in solvents
  • Real time saving of results
  • Export in a range of formats including .csv and .tsv
  • Export of data via USB flash drive, Ethernet or Wifi
  • Free PC Data Viewer software allows you to visualise data, spectra and Acclaro™ information offline
  • Cloud connectivity with the Thermo Fisher Cloud providing secure data backup and viewing user a web browser interface
  • Intuitive search functionality with User Identifiers
  • Connect a Dymo Labelwriter 450 for lab notebook friendly adhesive label printouts
  • Printing of spectral data or reports to Wi-Fi network printers or USB connected printers
  • Full wavelength scans from 190-850 nm using the UV-Vis module
  • OD 600 measurements with cell number conversion option
  • Create your own Custom Methods using the free PC Data Viewer software
  • Download pre-configured methods including cholorophyll and gold nanoparticles
  • For the NanoDrop™ One C model perform kinetic assays using the integrated cuvette reader with heater and magnetic stirrer
"Fast, reliable, and simplifies spectrophotometry even further."

"Great piece of kit, even easier to get reliable results quickly. Love the built in guidance and trouble shooting, small footprint and simplified so it's equally effective for all users."

NanoDrop in action

Find out how NanoDrop technology is helping the team at the Department of Chemistry at Cambridge improve their research on the chemical biology of nucleic acids.

"I think the NanoDrop one has really good troubleshooting and for its ability to show contaminants in DNA samples."

Robyn Hardisty
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Acclaro in action

Learn how the presence of contaminants in nucleic acid samples can affect downstream applications and how the NanoDrop One provides a clearer picture of your sample quality

Specifications

Instrument Control

Built-in touchscreen

Minimum Sample Volume

1 µL

Limit of Detection

dsDNA Pedestal: 2.0 ng/µL Cuvette: 0.2 ng/µL

BSA (IgG) Pedestal: 0.06 (0.03) mg/mL Cuvette: 0.006 (0.003) mg/mL

Maximum Concentration

dsDNA Pedestal: 27,500 ng/µL
BSA (IgG) Pedestal: 820 (400) mg/mL

Measurement and Data Processing Time

8 seconds

Dimensions (W × D × H)

20 × 25.4 × 32.3 cm (8 × 10 × 12.7 in.)

Weight

3.6 kg (7.9 lbs.)

Connectivity

Three USB-A ports, Ethernet, Bluetooth® and WiFi 3

PC Software Requirements

Windows® 7 and 10, 64 bit

Documents

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